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Serrapeptase Serrasyn® The Silkworm Enzyme – What is Serrapeptase?

What is Serrapeptase?

Serrapeptase Serrasyn® The Silkworm Enzyme

Serrasyn® is a high quality pharmaceutical grade Serrapeptase formulation which is defined by some as the miracle enzyme, also known as the silkworm enzyme, being actually produced by a friendly bacterium found naturally within the silkworm. The enzyme is utilised by the silkworm to dissolve its protective cocoon without having a detrimental effect on the living cells of the emerging silkmoth. The bacterium responsible for this enzyme is Serratia E15 and the enzyme is also known as Serratia peptidase. The enzyme was discovered in the early 1970’s and is now produced commercially as Serrsyn® through a fermentation process ensuring that the silkworm population is not affected.

Serrapeptase References


  • Kee WH. Tan SL, Lee V. Salmon YM. The treatment of breast engorgement with Serrapeptase: a randomised double blind controlled trial. Singapore Med J. 1989:30(1): 48-54.
  • Mizukoshi, D. et al. A double blind clinical study of Serrapeptase in the treatment of chronic sinusitis. Igaku Ayrni 109:50-62.1979.
  • Carratu, L. et al. Physio-chemical and rheological research on mucolytic activity of Serrapeptase in chronic broncho-pneumopathies. Curr. Ther. Res. 28(6): 937-951. 1980.
  • Braga, P.C. et al. Effects of Serrapeptase on muco-ciliary clearance in patients with chronic bronchitis. Curr. Ther. Res. 29(5): 738-744,1981.
  • Mazzonie, A. et al. Evaluation of Serrapeptase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double blind randomised trial versus placebo. J. Int. Med. Res. 18(5): 379-388,1990.
  • Kakinumu, A. et al. Regression of fibrinolysis in scalded rats by administration of Serrapeptase. Biochem. Pharmacol. 31:2861-2866,1982.
  • Marly, M. Enzymotherapie anti-inflammatoire a l’aide de la Serrapeptase: resultats cliniques en traumatologie et en ORL. C RTherapeut. 3:9-19,1985.
  • Odagiri, J. et al. Clinical applications of Serrapeptase in sinusitis. Med. Consult. New Remedy 6:201-209, 1979.
  • Yamazaki, J. et al. Anti-inflammatory activity of Serrapeptase, a protease produced by a strain of Serratia. Folia Pharmacol. Japon. 6^302-314,1967.
  • Harad, Y. Clinical efficacy of Serrapeptase on buccal swelling after radical operation for chronic sinusitis. Igaku Ayumi 123:768-778.1982.
  • Matsudo, A. et at. Effect of Serrapeptase on inflammatory oedema following operation for thyropid disease. Med. Consult. New Remedy 18:171-175, 1981.
  • Fujitani, T. et al. Effect of anti-inflammatory agent on transfer of antibiotics to the maxillary sinus mucosa in chronic sinusitis. Otorhinolaryngol. Clin. North Am. 66:557-565. 1976.
  • Tago. T. and Mitsui, S. Effects of Serrapeptase in dissolution of sputum, especially in patients with bronchial asthma. Jap. Clin. Exp. Med. 49:222-228, 1972.
  • Mazzonie, A. et al. Evaluation of Serrapeptase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double blind randomised trial versus placebo. J. int. Med. Res. 18(5): 379-388,1990.
  • Kase, Y. et al. A new method for evaluating mucolytic expectorant activity and its application. II. Application to two proteolytic enzymes, Serrapeptase and seaprose. Arzneimittelforschung 32:374-378,1982.
  • Marriott, C. Modification of the rheoloaical properties of mucus by drugs. Adv. Exp. Med. Biol. 144^75-84, 1982.
  • Majima. Y. et al. Effects of orally administered drugs on dynamic viscoelasticity of human nasal mucus. Am. Rev. Respit. Dis. 141:79-83.1990.
  • Miyata, K. Intestinal absorption of Serrapeptase. J ApplBiochem. 1980:2:111-16.
  • Aso T. et al. Breast engorgement and its treatment: Clinical effects of (Serrapeptase) an anti-inflammatory enzyme preparation. The world of Obstetrics and Gynaecology (Japanese). 1981:33:371-9.
  • Esch PM, Gemgross H. Fabian A. Reduction of postoperative swelling. Objective measurement of swelling of the upper ankle joints in treatment with Serrapeptase a prospective study (German). FortschrMed. 1989; 107(4): 67-8, 71-2.
  • Majima Y, lnagaki M, Hirata K. Takeuchi K, M orishita A, Sakakura Y. The effect of an orally administered proteolytic enzyme on the elasticity and viscosity of nasal mucus. Arch Otorhinolaryngol. 1988; 244(6):355-9.
  • Selan L, Berlutti F, Passariello C. Comodi-Ballanti MR, Thaller MC. Proteolytic enzymes: a new treatment strategy for prosthetic infections? Antimicrob Agents Cheroother. 1993; 37(12): 2618-21.
  • Koyama A, Mori J, Tokuda H, Waku M, Anno H, Katayama T, Murakami K, Komatsu H, Hirata M, Arai T, et al. Augmentation by Serrapeptase of tissue permeation by cefotiam (Japanese). Jpn JAntibiot. 1986; 39(3): 761-71

Serrasyn 250,000iu Review

TOP 500 REVIEWERon 2 March 2016
Verified Purchase

I’ve been using a different brand of serrapeptase for the last few months (80,000 I.U – taking 4 a day) but thought I’d give this one a try as its a higher strength so I only need to take one a day.

I’ve done a lot of research in to the benefits of serrapeptase – it has amazing anti-inflammatory benefits & is believed to be a pain blocker.

Personally I’ve been taking it to relieve joint pains (I suffer with an under active thyroid & aches are one of the symptoms) & painful periods.
Within a week or two I really noticed the pains in my joints easing, and my period was pretty pain free (and have remained so ever since).
I was so impressed that I recommended them to my husband who has suffered with painful knees for many years following an injury. He too found that over a few weeks his pain subsided.

I also recommended them to my daughter, she has quite severe endometriosis and has found that after a few weeks her pains have gone & she has had what she considers to be a normal menstruation for the first time in 10 years (her pains were so severe previously that she’d have fainting fits & be bed bound for days).

My mother is also taking them to see if they help with her asthma & breathing difficulties – so far she’s found her constant cough has subsided (after 1 month) and she’s hoping the breathlessness will ease too given a bit more time.

The tablets are smooth, round and a bit smaller than a typical ibuprofen. Serrapeptase is an enzyme which breaks down dead tissue – so great for scar tissue. It’s also good for reducing mucus in the respiratory tract along with too many other benefits to list!!

Serrapeptase must be taken on an empty stomach – it won’t cause any harm if taken with food however the enzymes will work on digesting your food rather than the places within your body that need help!

I strongly recommend this brand – excellent quality, easy to swallow & very fast delivery.